Endocrine Abstracts

Introduction: Autoimmune thyroid disease is often associated with other autoimmune diseases. Coeliac disease is one of those autoimmune diseases, together with is wide spectrum of intestinal and extraintestinal manifestations. Atrophy of intestinal mucosa, one of the characteristics of coeliac disease, among everything else, leads to poor absorption of l-tyroxine used in therapy of hypothyroidism.Aim and results: We like to present a clinical case of our...

Ghrelin is a growth hormone secretagogue that plays an important role in appetite and weight regulation. We have previously demonstrated that central ghrelin stimulated pituitary ACTH synthesis and secretion. In this study we further examined the effects of intracerebroventricular (ICV) ad-mi-nistration of ghrelin on zona glomerulosa (ZG), zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex, as well as the blood concentrations of aldosterone, corticosterone a...

Aim of this study was to evaluate biochemical parameters of thyroid gland function, used in evaluation of levothyroxine (L-T4) dose titration during a long time period in hypothyroid patients.Patients and methods: About 32 hypothyroid women were included in our study. All patients were euthyroid for a long time, treated with levothyroxine replacement therapy, taking an individually titrated daily dosage (50–100 μg). Blood samples...

Introduction: Some recent data indicates that high levels of homocysteine (Hcy) can be independent risk factor for osteoporosis and fractures in elderly. There are few explanations how homocysteine influence bone resorption and probably modify effect of therapy for osteoporosis. 1. Hcy interferes with collagen cross-linking. 2. High levels of Hcy specially stimulate resorptive activity of osteoclasts in vitro. 3. Hcy interfere bisphosphonates binding to hydroxyapatite.<...

Introduction: Prevalence of celiac disease (gluten enteropathy) in general population is around 1:100–300. Half of these patients are women. Most common age for diagnose is third year or third to fourth decade of life, due to mild clinical signs. In the moment of diagnosis, 30% of patients already have lowered bone mineral density (BMD). Pathophysiologic mechanism for lowering BMD is secondary, regulative, intestinal hyperparathyroidism.Aim: To trac...

COGHD may be of genetic origin associated with deficiency of other pituitary hormones. Non treatment with GH in these cases can cause metabolic and other disturbances. The aim of this research was examining consequences of non treated COGDH in three sisters with familial hypopituitarism. Three sisters 60-, 59- and 54-year-old with familial hypopituitarism (GH,TSH, gonadotropin and prolactin deficiency) which was diagnosed 46 years before were examined. Substitution therapy per...

Objectives: The selective estrogen receptor modulator, raloxifene, exerts a part of its actions through the estrogen receptor alpha activation. We explored if polymorphisms of ESR1 gene modify the effects of 6 months raloxifene treatment on endothelial function.Methods: Two intronic (PvuII and XbaI), and one exonic polymorphism (P325P) of ESR1 were analyzed in 53 postmenopausal women, mean age 59.7+6.2. The flow mediated endothelium ...

The different response of somatotropic system to genistein and daidzein in the rat hypothalamus: Svetlana Trifunović, Branka Šošić-Jurjević, Milica Manojlović-Stojanoski, Nataša Ristić, Nataša Nestorović, Branko Filipović, Verica MiloševićUniversity of Belgrade, Institute for Biological Research ‘Siniša Stanković’, Department of Cytology, Belgrade, Serbia The different r...

Personalized medicine is a crucial part of modern medicine. As a result, other therapeutic options apart from levothyroxine are considered when treating hypothyroidism. Desiccated thyroid pharmaceuticals, that in addition to thyroxine (T4), contain triiodothyronine (T3), are one of them. ETA recognized the rapid use of desiccated thyroid pharmaceuticals and described specific guidelines for its utilization. The biggest problem of their use is unresolved issues of content that ...

Aging is a complex process characterized by a progressive decline in cellular function, alterations of the endocrine system and the increased incidence of thyroid diseases. Citrus flavanones naringenin (NAR) and hesperetin (HES) may contribute to maintenance of health at old age however they may also affect thyroid hormone economy. The aim of this study was to test weather NAR or HES administration alter thyroid functioning. NAR or HES were administrated orally (15 mg/kg) to m...